Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System

From Biology to Drug Discovery
by Nicholas J. Brandon & Anthony R. West

Publisher: Wiley

Series: Wiley Series in Drug Discovery and Development

Publication Date: April 22, 2016

ISBN: 9781118836309

Binding: Kobo eBook

Availability: eBook

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This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.